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KMID : 0363220070450060635
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Korean Journal of Dermatology
2007 Volume.45 No. 6 p.635 ~ p.639
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Two Cases of Antituberculosis Drug-induced Hypersensitivity Syndrome
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Yoon Ho-Joon
Shin Wan-Shik
Lee Dong-Hoon
Suh Dae-Hun
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Abstract
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Drug-induced hypersensitivity syndrome is a rare, but severe, life-threatening disease with multiorgan failure. Aromatic antiepileptic drugs are frequent causes of this syndrome. The association of the human herpes virus-6 has been recently reported in patients with drug-induced hypersensitivity syndrome. We report two patients who were diagnosed as having antituberculosis drug-induced hypersensitivity syndrome based on clinical course and laboratory data. In addition, human herpes virus-6 DNA was detected by polymerase chain reaction in peripheral blood mononuclear cells and the serum. There was a favorable outcome after discontinuation of the causative drug, plus corticosteroid therapy. After the treatment, human herpes virus-6 DNA was not detected by polymerase chain reaction. This is the first report of antituberculosis drug-induced hypersensitivity syndrome associated with reactivation of human herpes virus-6.
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KEYWORD
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Antituberculosis Drug, Drug-induced Hypersensitivity Syndrome, Human herpes virus-6
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